Below is the 2010 Mississippi State Football Schedule. If you want to see every single Mississippi State Football Schedule from past to present, check back soon and we'll have that up for you.
| Date | Opponent | Result | ||
| Sep 4, 2010 | vs | Memphis | ||
| Sep 11, 2010 | vs | Auburn | ||
| Sep 18, 2010 | at | LSU | ||
| Sep 25, 2010 | vs | Georgia | ||
| Oct 2, 2010 | vs | Alcorn | ||
| Oct 9, 2010 | at | Houston | ||
| Oct 16, 2010 | at | Florida | ||
| Oct 23, 2010 | vs | UAB | ||
| Oct 30, 2010 | vs | Kentucky | ||
| Nov 6, 2010 | - | OPEN | ||
| Nov 13, 2010 | at | Alabama | ||
| Nov 20, 2010 | vs | Arkansas | ||
| Nov 27, 2010 | at | Ole Miss | ||
| Dec 4, 2010 | at | SEC Championship Game (Atlanta) | ||